Case Studies in Immunology, Sixth Edition, is intended for medical students and undergraduate and graduate students in immunology and presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case. The book includes a total of 53 cases and can be used as either a stand-alone text, review aid, or as a companion to Janeway’s Immunobiology, Eighth Edition, and The Immune System, Third Edition. The Sixth Edition is extensively revised and updated and includes ten new cases: DiGeorge Syndrome Familial Hemophagocytic Lymphohistocytosis Chediak-Higashi Syndrome Hyper IgE Syndrome Ataxia-telangiectasia Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM syndrome) Severe Congenital Neutropenia Recurrent Herpes Simplex Encephalitis Juvenile Arthritis Crohn’s Disease