Antiphospholipid syndrome (APS) belongs to the group of rheumatic diseases and is characterized by the presence of autoantibodies to phospholipids. The reasons for the formation of antibodies are not fully understood. The monograph identifies the role of antiphospholipid syndrome in the development of cerebrovascular diseases in systemic connective tissue diseases. early diagnosis of patients, reducing disease in their treatment, and increasing the effectiveness of treatment. The monograph is intended for neuropathologists and general practitioners, rheumatologists, as well as master's and clinical residency students.