In this issue of Neurosurgery Clinics, Drs. Chang and Barbaro provide a thorough look at epilepsy, with sections focusing on devices in epilepsy surgery, open loop systems, closed loop systems, and non-stimulation. Topics in this issue include history and overview of stimulation for epilepsy, trigeminal nerve stimulation, anterior thalamus DBS, hippocampal stimulation, neuropace RNS, seizure detection/prediction algorithms, cooling, seizure prediction and its applications, stimulation paradigms, and experimental stimulation.